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Histamine-2 (H2) receptor antagonists block the release of acid in response to gastrin or parasympathetic release. Histamine-2 Antagonist: Generic and Brand NamesHere is a table of the most commonly used H2 antagonists.
DescriptionHistamine-2 antagonists block the release of hydrochloric acid in response to gastrin.
Therapeutic actionsThe desired actions of H2 antagonists include the following:
IndicationHistamine-2 antagonists are indicated for the following:
PharmacokineticsCimetidine, ranitidine, and famotidine are available in oral and parenteral forms
Contraindications and CautionsThe contraindications and cautions when using H2 antagonists include:
Adverse effectsThe adverse effects associated with H2 antagonists are:
InteractionsCimetidine, famotidine, and ranitidine can slow down the metabolism of the following drugs, leading to increased serum levels and possible toxic reactions: Nursing considerations for a patient using H2 antagonists include the following: Nursing AssessmentNursing assessment for a patient using H2 antagonists include:
Nursing DiagnosisNursing diagnosis related to the drug therapy might include the following: Nursing Care Plans and InterventionsNursing interventions for patients using H2 antagonists include:
EvaluationEvaluation of a patient using H2 antagonists include:
Quiz1. Which of the following best describes the method of action of medications, such as ranitidine (Zantac), which are used in the treatment of peptic ulcer disease? A. Neutralize acidB. Reduce acid secretionsC. Stimulate gastrin release D. Protect the mucosal barrier 1. Answer: B. Reduce acid secretions.
2. A client is to take one daily dose of ranitidine (Zantac) at home to treat her peptic ulcer. The nurse knows that the client understands proper drug administration of ranitidine when she says that she will take the drug at which of the following times? A. Before mealsB. With mealsC. At bedtime D. When pain occurs 2. Answer: C. At bedtime.
3. The nurse provides medication instructions to a client with peptic ulcer disease. Which statement, if made by the client, indicates the best understanding of the medication therapy? A. “The cimetidine (Tagamet) will cause me to produce less stomach acid.” B. “Sucralfate (Carafate) will change the fluid in my stomach.” C. “Antacids will coat my stomach.” D. “Omeprazole (Prilosec) will coat the ulcer and help it heal.” 3. Answer: A. “The cimetidine (Tagamet) will cause me to produce less stomach acid.”
4. When a client has peptic ulcer disease, the nurse would expect a priority intervention to be: A. Assisting in inserting a Miller-Abbott tube B. Assisting in inserting an arterial pressure line C. Inserting a nasogastric tube D. Inserting an I.V. 4. Answer: C. Inserting a nasogastric tube.
5. A 40-year-old male client has been hospitalized with peptic ulcer disease. He is being treated with a histamine receptor antagonist (cimetidine), antacids, and diet. The nurse doing discharge planning will teach him that the action of cimetidine is to: A. Reduce gastric acid output. B. Protect the ulcer surface. C. Inhibit the production of hydrochloric acid (HCl). D. Inhibit vagus nerve stimulation. 5. Answer: A. Reduce gastric acid output.
Recommended ResourcesRecommended resources and reference books. Disclosure: Includes Amazon affiliate links. See AlsoHere are other nursing pharmacology study guides:
Gastrointestinal System Drugs
Respiratory System Drugs Endocrine System Drugs Autonomic Nervous System Drugs Immune System Drugs Chemotherapeutic Agents Reproductive System Drugs
Nervous System Drugs Cardiovascular System Drugs ReferencesSuggested reading and references for this Histamine 2 Receptor Antagonist Nursing Pharmacology Guide:
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